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十博体育官网:不断进化的应用
栏目:十博新闻 发布时间:2020-07-01
AMP的高效协同作用
本期文章:《科学》:Volume 368 Issue 6490

德国柏林自由大学Jens Rolff等研究人员总结了十博体育官网的认识和应用前景。这一综述论文于2020年5月1日发表在国际学术期刊《科学》上。

研究人员表示,十博体育官网(AMP)是多细胞生物免疫防御的重要组成部分,目前正作为抗感染药进行开发。传统上认为AMP具有广谱活性和简单的动力学,但最近的证据表明,AMP具有出乎意料的特异性和高协同作用能力。

对AMP体育网分子进化和群体遗传的深入评估发现,与以前认为的相比,AMP体育网多态性的适应性维持以及AMP活性的适应性丢失更为常见。AMP表现出可降低目标微生物耐药性进化的药理动态性质,并且AMP可以彼此协同作用,也可以与常规抗生素协同作用。

这两个特性使AMP在转化应用中具有吸引力。研究人员认为,如果要在临床上使用AMP,了解其天然生物学则至关重要,从而减少附带损害的风险并避免目前常规抗生素面临的耐药性危机。

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附:英文原文
Title: Antimicrobial peptides: Application informed by evolution

Author: Brian P. Lazzaro, Michael Zasloff, Jens Rolff

Issue&Volume: 2020/05/01

Abstract: Antimicrobial peptides (AMPs) are essential components of immune defenses of multicellular organisms and are currently in development as anti-infective drugs. AMPs have been classically assumed to have broad-spectrum activity and simple kinetics, but recent evidence suggests an unexpected degree of specificity and a high capacity for synergies. Deeper evaluation of the molecular evolution and population genetics of AMP genes reveals more evidence for adaptive maintenance of polymorphism in AMP genes than has previously been appreciated, as well as adaptive loss of AMP activity. AMPs exhibit pharmacodynamic properties that reduce the evolution of resistance in target microbes, and AMPs may synergize with one another and with conventional antibiotics. Both of these properties make AMPs attractive for translational applications. However, if AMPs are to be used clinically, it is crucial to understand their natural biology in order to lessen the risk of collateral harm and avoid the crisis of resistance now facing conventional antibiotics.

DOI: 10.1126/science.aau5480

Source: 
https://science.sciencemag.org/content/368/6490/eaau5480


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